Huwaida is a Palestinian-American, and also a citizen of Israel. She received her Bachelors degrees from the University of Michigan, and her Juris Doctor from the American University Washington College of Law, where she focused her studies on international human rights and humanitarian law.
In 2001 Huwaida co-founded the International Solidarity Movement (ISM), which has twice been nominated for the Nobel Peace Prize. From 2007 - 2008 Huwaida taught in a human rights law clinic at Al-Quds University in Jerusalem, the first legal clinic in the Arab World.
Huwaida was one of the initiators and organizers of a delegation of American lawyers to Gaza in February 2009, and co-authored the report on their findings, "Onslaught: Israel's Attack on Gaza and the Rule of Law."